Hot Papers in Molecular Imaging
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  • Adams J, Johnson D, Sato M, Berger F, Gambhir SS, Carey M, Iruela-Arispe L, Wu L. Visualization of Advanced Human Prostate Cancer Lesions in Living Mice by a Targeted Gene Transfer Vector and Optical Imaging. Nature Medicine, 8(8): 891-896, 2002

  • Adonai N, Nguyen K, Walsh J, Iyer M, Toyokuni T, Phelps ME, McCarthy T, McCarthy D, Gambhir SS. Ex Vivo Cell Labeling with 64Cu-Pyruvaldehyde-Bis(N4-Methylthiosemicarbazone) for Imaging Cell Trafficking in Mice with Positron Emission Tomography. Proceedings of the National Academy of Science (USA), 99(5): 3030-3035, 2002.

  • Andreopoulos D, Kasi LP, Asimacopoulos PJ, Jhingran SJ, Cole W, Yang D, Kim EE. Selective in vitro labeling of white blood cells using 99mTc-labeled liposomes. Nucl Med Biol, 29(2):185-90, Feb 2003.

  • Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA. Epidermal growth factor receptor and Ink4a/Arf. Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell. 2002 Apr;1(3):269-77.

  • Berger F, Lee YP, Loening A, Chatziioannou A, FreedlandS, Leahy R, Liberman JR, Beldegrun A, Sawyers CL, Gambhir SS. Whole Body Skeletal Imaging in Mice Utilizing MicroPET: Optimization of Reproducibility and Applications in Animal Models of Bone Disease. European Journal of Nuclear Medicine, 29(9): 1225-1236, 2002.

  • S. Bhaumik, S.S. Gambhir. Optical imaging of Renilla luciferase reporter gene expression in living mice. PNAS. 2002 Jan 8;99(1):377-382.

  • Blasberg R. Imaging gene expression and endogenous molecular processes: molecular imaging. J Cereb Blood Flow Metab 2002 Oct 22(10):1157-64

  • Blasberg R. PET imaging of gene expression. Eur J Cancer, 38(16):2137-46, Nov 2002.

  • Blasberg RG, Gelovani-Tjuvajev J. In vivo molecular-genetic imaging. Cell Biochem Suppl, 39:172-83, 2002.

  • Bluml S, Moreno-Torres A, Shic F, Nguy CH, Ross BD. Tricarboxylic acid cycle of glia in the in vivo human brain. NMR Biomed. 2002 Feb;15(1):1-5.

  • Bogdanov AA Jr, Lin CP, Simonova M, Matuszewski L, Weissleder R. Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment. Neoplasia. 2002 May-Jun;4(3):228-36.

  • Bremer C, Tung CH, Bogdanov A Jr, Weissleder R. Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes. Radiology. 2002 Mar;222(3):814-8.

  • Boute N, Jockers R, Issad T. The use of resonance energy transfer in high-throughput screening: BRET versus FRET. Trends Pharmacol Sci. 2002 Aug;23(8):351-4.
  • Chen J, Tung CH, Mahmood U, Ntziachristos V, Gyurko R, Fishman MC, Huang PL, Weissleder R. In vivo imaging of proteolytic activity in atherosclerosis. Circulation. 2002 Jun 11;105(23):2766-71.

  • Contag PR. Whole-animal cellular and molecular imaging to accelerate drug development. Drug Discov Today. 2002 May 15;7(10):555-562.

  • Gambhir, SS. Molecular Imaging of Cancer with Positron Emission Tomography. Nature Reviews Cancer, 2(9): 683-693, 2002.

  • Goertzen AL, Meadors AK, Silverman RW, Cherry SR. Simultaneous molecular and anatomical imaging of the mouse in vivo. Phys\ Med Biol, 47(24):4315-28, Dec 2002.

  • Groot-Wassink T, Aboagye EO, Glaser M, Lemoine NR, Vassaux G. Adenovirus biodistribution and noninvasive imaging of gene expression in vivo by positron emission tomography using human sodium/iodide symporter as reporter gene. Hum Gene Ther 2002 Sep 13(14):1723-35.

  • Hamblin MR, O'Donnell DA, Murthy N, Contag CH, Hasan T. Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging. Photochem Photobiol. 2002 Jan;75(1):51-7.

  • Hogemann D, Ntziachristos V, Josephson L, Weissleder R. High throughput magnetic resonance imaging for evaluating targeted nanoparticle probes. Bioconjug Chem. 2002 Jan-Feb;13(1):116-21.

  • Issad T, Boute N, Pernet K. A homogenous assay to monitor the activity of the insulin receptor using Bioluminescence Resonance Energy Transfer. Biochem Pharmacol. 2002 Sep;64(5-6):813-7.

  • Issad T, Boute N, Pernet K. The activity of the insulin receptor assessed by bioluminescence resonance energy transfer. Ann N Y Acad Sci. 2002 Nov;973:120-3.

  • Iyer M, Berenji M, Templeton NS, Gambhir SS. Non-Invasive Imaging of Cationic Lipid Mediated Delivery of Optical and PET Reporter Genes in Living Mice. Molecular Therapy. Mol Ther. 2002 Oct;6(4):555-62.

  • Jaffer FA, Tung CH, Gerszten RE, Weissleder R. In Vivo Imaging of Thrombin Activity in Experimental Thrombi With Thrombin-Sensitive Near-Infrared Molecular Probe. Arterioscler Thromb Vasc Biol. 2002;22:1929-1935.

  • Jayson GC, Zweit J, Jackson A, Mulatero C, Julyan P, Ranson M, Broughton L, Wagstaff J, Hakannson L, Groenewegen G, Bailey J, Smith N, Hastings D, Lawrance J, Haroon H, Ward T, McGown AT, Tang M, Levitt D, Marreaud S, Lehmann FF, Herold M, Zwierzina H. Molecular Imaging and Biological Evaluation of HuMV833 Anti-VEGF Antibody: Implications for Trial Design of Antiangiogenic Antibodies. J Natl Cancer Inst 2002 Oct 94(19):1484-93.

  • Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R. Near-Infrared Fluorescent Nanoparticles as Combined MR/Optical Imaging Probes. Bioconjug Chem. 2002 May-Jun;13(3):554-60.

  • Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A Jr. Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjug Chem. 2002 Jan-Feb;13(1):122-7.

  • Lee SY, Wang Z, Lin CK, Contag CH, Olds LC, Cooper AD, Sibley E. Regulation of intestine-specific spatiotemporal expression by the rat lactase promoter. J Biol Chem. 2002 Apr 12;277(15):13099-105.

  • Lin Y, Weissleder R, Tung CH. Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation. Bioconjug Chem. 2002 May-Jun;13(3):605-10.

  • Le LQ, Kabarowski JHS, Wong S, Nguyen K, Gambhir SS, and Witte ON.Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene. Cancer Cell. 2002; 1(4): 381-391.

  • Liang Q, Gotts J, Satyamurthy N, Barrio J, Phelps ME, Gambhir SS, Herschman HR. Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus. Mol Ther. 2002 Jul;6(1):73-82.

  • Luker GD, Sharma V, Pica CM, Dahlheimer JL, Li W, Ochesky J, Ryan CE, Piwnica-Worms H, and Piwnica-Worms D. Noninvasive imaging of protein-protein interactions in living animals. PNAS. 2002; 99(10): 6961-6966.

  • Mahmood U, Weissleder R. Some tools for molecular imaging. Acad Radiol. 2002 Jun;9(6):629-31.

  • Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, Weissleder R. Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterology. 2002 Feb;122(2):406-14.

  • P. Mayer-Kuckuk, D. Banerjee, S. Malhotra, M. Doubrovin, M. Iwamoto, T. Akhurst, J. Balatoni, W. Bornmann, R. Finn, S. Larson, Y. Fong, J. G. Tjuvajev, R. Blasberg, and J. Bertino. Cells exposed to antifolate show increased cellular levels of proteins fused to dihydrofolate reductase: A method to modulate gene expression. PNAS. 2002; 99(6): 3400-3405.

  • McCarthy T, Sheriff A, Graneto M, Talley J, Welch M. Radiosynthesis, In Vitro Validation, and In Vivo Evaluation of 18 F-Labeled COX-1 and COX-2 Inhibitors. JNM 2002; 43:117-124.

  • Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK. Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model. Neoplasia. 2002 Jan-Feb;4(1):3-8.

  • Moore A, Sun PZ, Cory D, Hogemann D, Weissleder R, Lipes MA. MRI of insulitis in autoimmune diabetes. Magn Reson Med. 2002 Apr;47(4):751-8.

  • Ntziachristos V, Tung CH, Bremer C, Weissleder R. Fluorescence molecular tomography resolves protease activity in vivo. Nat Med. 2002 Jul;8(7):757-61.

  • Ntziachristos V, Weissleder R. Harge-coupled-device based scanner for tomography of fluorescent ear-infrared probes in turbid media. Med Phys. 2002 May;29(5):803-9.

  • Nyati MK, Symon Z, Kievit E, Dornfeld KJ, Rynkiewicz SD, Ross BD, Rehemtulla A, Lawrence TS. The potential of 5-fluorocytosine/cytosine deaminase enzyme prodrug gene therapy in an intrahepatic colon cancer model. Gene Ther. 2002 Jul;9(13):844-9.

  • Pham W, Weissleder R, Tung CH. An azulene dimer as a near-infrared quencher. Angew Chem Int Ed Engl. 4;41(19):3659-62, 3519, Oct 2002.

  • Perez JM, O'Loughin T, Simeone FJ, Weissleder R, Josephson L. DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents. J Am Chem Soc. 2002 Mar 27;124(12):2856-7.

  • Price P, Jones T. Molecular imaging: what picture does it paint for future oncology? Drug Discov Today, 7(14):741-3, July 2002.

  • Qiao J, Doubrovin M, Sauter BV, Huang Y, Guo ZS, Balatoni J, Akhurst T, Blasberg RG, Tjuvajev JG, Chen SH, Woo SL. Tumor-specific transcriptional targeting of suicide gene therapy. Gene Ther. 2002 Feb;9(3):168-75.

  • Ray P, Pimenta H, Paulmurugan R, Berger F, Phelps ME, Iyer M, Gambhir SS. Noninvasive quantitative imaging of protein-protein interactions in living subjects. PNAS. 2002; 99(5), 3105-3110.

  • Seltzer MA, Yap CS, Silverman DH, Meta J, Schiepers C, Phelps ME, Gambhir SS, Rao J, Valk PE, Czernin J. The Impact of PET on the Management of Lung Cancer: The Referring Physician's Perspective. J Nucl Med. 2002 Jun;43(6):752-6.

  • Semenov SY, Svenson RH, Bulyshev AE, Souvorov AE, Nazarov AG, Sizov YE, Posukh VG, Pavlovsky A, Repin PN, Starostin AN, Voinov BA, Taran M, Tatsis GP, Baranov VY. Three-dimensional microwave tomography: initial experimental imaging of animals. IEEE Trans Biomed Eng. 2002 Jan;49(1):55-63.

  • Schiff ND, Ribary U, Moreno DR, Beattie B, Kronberg E, Blasberg R, Giacino J, McCagg C, Fins JJ, Llinas R, Plum F. Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain. Brain. 2002 Jun;125(Pt 6):1210-34.

  • Tsourkas A, Behlke MA, Bao G. Hybridization of 2'-O-methyl and 2'-deoxy molecular beacons to RNA and DNA targets. Nucleic Acids Res 2002 Dec 30(23):5168-74.

  • Tung CH, Gerszten RE, Jaffer FA, Weissleder R. A novel near-infrared fluorescence sensor for detection of thrombin activation in blood. Chembiochem. 2002 Mar 1;3(2-3):207-11.

  • Wang Y, Yu YA, Shabahang S, Wang G, Szalay AA. Renilla luciferase- Aequorea GFP (Ruc-GFP) fusion protein, a novel dual reporter for real-time imaging of gene expression in cell cultures and in live animals. Mol Genet Genomics 2002 Oct 268(2):160-8.

  • Weissleder R. Scaling down imaging: molecular mapping of cancer in mice. Nature Rev Cancer. 2002 Jan;2(1):11-8.

  • Wu J, Inubushi M, Sundaresan G, Schelbert HR, Gambhir SS. Optical Imaging of Cardiac Reporter Gene Expression in Living Rats. Circulation, 105: 1631-1634, 2002.

  • Wu J, Inubushi M, Sundaresan G, Schelbert HR, Gambhir SS. Positron Emission Tomography Imaging of Cardiac Reporter Gene Experssion in Living Rats. Circulation, 106:180-183, 2002.

  • Wunderbaldinger P, Josephson L, Weissleder R. Tat Peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug Chem. 2002 Mar-Apr;13(2):264-8.

  • Wunderbaldinger P, Josephson L, Bremer C, Moore A, Weissleder R. Detection of lymph node metastases by contrast-enhanced MRI in an experimental model. Magn Reson Med. 2002 Feb;47(2):292-7.